Proposed mechanism of 2′,3′-cAMP in SG formation due to its interaction with Rbp47b. Stress conditions (e.g. heat) induce translational arrest as well as RNA breakdown. The activity of the 3′ to 5′ RNA nucleases leads to the accumulation of 2′,3′-cyclic nucleotides, which consequently bind to Rbp47b. The binding of 2′,3′-cAMP and mRNA facilitates Rbp47b self-assembly, thereby promoting SG formation.