NO-mediated inhibition of HDACs might contribute to stress gene induction. In nonchallenged conditions, HDAC complexes repress the transcription of stress-responsive genes by deacetylation of the corresponding chromatin regions. Upon exposure to stress, NO is produced, resulting in the inhibition of HDAC complexes. This might activate transcription in tight interplay with transcription factors. Blue cylinders, Nucleosomes; green circles, acetyl groups (Ac); black arrow, TSS.