Potential associations between predictive score and functional alteration or phenotypic severity. The SCN1A variants with functional alteration confirmed (A) or documented phenotype (B) were analyzed. Predictive scores were generated by the representative tool SNAP2. According to the Spearman’s rank correlation analysis, the predictive scores had a positive correlation with ranks of functional alteration (r = 0.408, P = 0.004) and phenotypic severity (r = 0.670, P = 0.000).