The enrichment significance scores of MMS, MDS, DFVS and NCUA methods in the CSD list by respectively using the (A) LIONESS, (B) SSN and (C) Paired-SSN network constructing methods. The enrichment significant P-value is calculated by using the hyper geometric test [129]. The enrichment score ESg is defined as ESg = −log10(P-value). The red line denotes the significant threshold value ESG = 2. If the ESG for the predicted PDGs is larger than this threshold value, we think that the enrichment result is significant.