Schematic demonstration of MMS, MDS, DFVS and NCUA methods on the personalized state transition network constructed with the Paired-SSN method for patient ‘TCGA-BJ-A28W’ in THCA cancer. A sub-network (containing FGR gene and its neighborhood genes) of the personalized state transition network for the ‘TCGA-BJ-A28W’ cancer patient is chosen to evaluate the performance of MMS, MDS, DFVS and NCUA. The genes {BTK, ABL1, EPHA7} in the CCG gene list (within the rectangular box in blue color) and NCG gene list (within the rectangular box in green color) are considered as the gold standard driver genes. (A) MMS method found the matching edges (red color edges) which results 10 unmatched nodes (red color nodes). These 10 genes are considered as the driver genes in which there is one standard driver gene (EPHA7). (B) MDS method identified the MDS {FGR} (red color node) as driver genes in which there are no standard driver genes. MDS assumes that the driver node can independently control its associated edges (red color edges). (C) DFVS method identified the FVS node {DOK1} (red color node) that intersects two feedback loops as the driver genes in which there are no standard driver genes.(D) NCUA method identified four driver genes (red color nodes) which can cover all the edges (feedback loop) in the undirected network. There is one standard driver gene among four driver genes.