rut-dependent impairments in spatial learning are reversed by enhancing sleep. (A) Sleep profiles of rut²⁰⁸⁰ mutants was not different compared with Cs controls (n = 18–22 flies/genotype, n.s. p = 0.49, t-test). (B) Spatial Learning is impaired in rut²⁰⁸⁰ mutants compared with Cs controls (n = 9–10 flies/genotype,*p < 0.001, t-test). (C) rut²⁰⁸⁰ males are not impaired in heat avoidance (n = 10 flies/genotype, n.s. p = 0.27). (D) Gaboxadol increases total sleep in rut²⁰⁸⁰ flies compared with vehicle-fed siblings (n = 18–20 flies/condition, *p < 10⁻¹⁰, t-test). (E) Gaboxadol-fed rut²⁰⁸⁰ flies display increased average daytime sleep bout duration compared with vehicle-fed siblings (*p < 10^–4, t-test). (F) Gaboxadol restored spatial learning to rut²⁰⁸⁰ flies compared with controls (n = 9–10 flies/condition,*p < 0.01, t-test). (G) Gaboxadol did not impair the optomotor response of rut²⁰⁸⁰ flies (n = 19 flies/condition, n.s. p = 0.43, t-test).