Pedigrees of investigated families. Pedigrees of six families with bi-allelic variants in VWA1 in affected individuals. Filled black symbols = affected individuals; crossed symbols = deceased individual. Variants in VWA1 are presented below pedigrees. Homozygous variants are presented in bold (m in the pedigrees). Compound heterozygous mutations are presented in two rows (first row, m1 in the pedigrees and second row, m2 in the pedigrees).