Proposed framework for classifying coexisting mitral regurgitation and severe LV systolic dysfunction. This framework is based on ancillary analyses of randomized clinical trials and prospective validation is pending. ERO: effective regurgitant orifice. EDV: end-diastolic volume. TMVr: transcatheter mitral valve repair. (from Bermejo J, Postigo A, Baumgartner H. The year in cardiovascular medicine 2020: valvular heart disease. See pages 647–656).