Incomplete biomarker profile normalization during clinically inactive disease

(A) Principal component analysis of inactive patients (Inact) compared with healthy controls (HC). Open circles represent cluster centers. (B) Biomarker values in inactive (J)DM and EF compared with controls, in biomarkers with continuously elevated or reduced levels. Dotted line indicates cutoff for normal values set at mean ± 2 s.d. of HC. Percentages indicate percentage of patients above cutoff, per disease. P-values from Kruskal–Wallis test per disease with Dunn’s post hoc test are indicated: *P <0.05, **P <0.01, ***P <0.001, ****P <0.0001. (J)DM: (Juvenile) dermatomyositis; EF: eosinophilic fasciitis.