Risk of severe or critical COVID-19 in patients with FD. Given the scarcity of Fabry-specific information, this figure has extrapolated knowledge from the general population and the natural history of FD [1, 2]. It shows two scales, depending on whether data are available for specific patients on the extent of target organ injury. When this is known, the ‘Based on target organ injury’ scale should be used. When this is unknown, the ‘Based on age and sex’ scale provides some guidance. TIA, transient ischaemic attack; WML, white matter lesion; LVH, left ventricular hypertrophy.