Body weight changes and tissue tropism of SARS-CoV-2 infection in the Syrian hamster model. A, Body weight changes of SARS-CoV-2–challenged (n = 11 at 0 dpi to 7 dpi; n = 6 at 8 dpi to 14 dpi) and mock-infected (n = 3 at 0 dpi to 14 dpi) hamsters. B, Viral load by qRT-PCR assay in the respiratory tract tissues, extrapulmonary organ tissues, and blood of SARS-CoV-2–challenged hamsters at 2 dpi, 4 dpi, and 7 dpi (n = 3/day). C, Quantitation of virus titer by TCID₅₀ assay in the nasal turbinate and lung of SARS-CoV-2–challenged hamsters at 2 dpi, 4 dpi, and 7 dpi (n = 5/day). **P < .01, ***P < .0001 by 2-way ANOVA. Error bars represent SDs of the mean. Abbreviations: ANOVA, analysis of variance; dpi, days postinoculation; qRT-PCR, quantitative reverse transcription–polymerase chain reaction; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TCID₅₀, median tissue culture infectious dose.