Transcription factors potentially subjected to an auto-regulation. (A) Pie chart depicting the proportion of the 87 sequence-specific transcription factors from ENCODE ChIP-seq experiments (49) having a binding event in their own 5′ non-coding region (5′ non-coding exon and introns located before the CDS). (B) Table summarizing the number on binding events found in the 5′ non-coding region of the 39 sequence-specific transcription factors. For each factor the presence or absence of at least one intron in the 5′ non-coding region is mentioned.