miRs in cardiac (reverse) remodelling. The left side of the figure represents the changes in miRs levels during ventricular remodelling induced by several pathologies, such as aortic valve stenosis, myocardial infarction, and volume overload. The right side depicts changes in miRs levels during reverse remodelling triggered by interventions such as aortic valve replacement, left ventricle assist devices (LVAD) implantation, cardiac re-synchronization therapy (CRT), or treatment with β-blocker. These changes depend on the extent of myocardial reverse remodelling. Myocardial recovery is considered when RR leads to a total normalization of cardiac function and structure.