Proportion of cardiovascular deaths by estimated 10-year risk, observed in individuals aged 45–65 years during the first 10 years of follow-up. (a) Proportion of cardiovascular deaths by estimated 10-year risk of atherosclerotic cardiovascular disease (CVD) using the Pooled Cohort equations (PCEs), stratified by definite American College of Cardiology/American Heart Association (ACC/AHA) 2013 guideline treatment recommendations. (b) Proportion of cardiovascular deaths by 10-year risk of atherosclerotic CVD using the PCEs, stratified by eligibility for at least one out 11 randomised clinical trials (RCTs). (c) Proportion of cardiovascular deaths by estimated 10-year risk of CVD mortality using the Systematic Coronary Risk Evaluation (SCORE) equations, stratified by definite European Society of Cardiology (ESC) 2016 guideline recommendations. (d) Proportion of cardiovascular deaths by estimated 10-year risk of CVD mortality using the SCORE equations, stratified by eligibility for at least one out 11 RCTs.