Figure 3.
Identification of thresholds for gene expression biomarkers from the DrugMatrix study. A, Distribution of values derived from the DrugMatrix study. Thresholds were determined as detailed in the Materials and Methods section. Each of the biosets was compared with 1 of the 6 biomarkers generating a −Log(p value) of the correlation. The −Log(p value)s were rank ordered and divided into liver tumorigenic and nontumorigenic groups. Horizontal lines represent the derived thresholds. B, Box and whisker plots of −Log(p value)s from the nontumorigenic conditions. The 4 values deemed outliers are circled and were not used to determine the thresholds. Abbreviations: AhR, aryl hydrocarbon receptor; CAR, constitutive activated receptor; ER, estrogen receptor; PPARα, peroxisome proliferator-activated receptor α.