Supratoxic Mn exposures reduce glycolytic activity, but not glycolytic induction. A, (left and center) STHdh^Q7/Q7 basal and postoligomycin extracellular acidification oligomycin-extracellular acidification rates (OGM-ECAR) (pmol/min) per 10⁴ cells; (right) Percent change between OGM-ECAR and basal ECAR. B, (left and center) STHdh^Q111/Q111 basal ECAR and OGM-ECAR per 10⁴ cells, (right) percent change between OGM addition and basal ECAR. Mn concentrations (µM), after 24 h exposure, are indicated below the respective bars. Concentrations in red reflect concentrations above which significant cytotoxicity is observed. Results combined from 3 independent experiments, n = 6; total n = 18. Error bars reflect SEM. *p < .05, ***p < .001, by Dunnett’s test relative to control for each measurement.