Figure 2.
Calculation steps for development of Human Equivalent Dose from rat and age-related Data-derived Extrapolation Factor. Abbreviations: MC, Monte Carlo; PBPK, physiologically based pharmacokinetic; POD, point of departure.

Calculation steps for development of Human Equivalent Dose from rat and age-related Data-derived Extrapolation Factor. Abbreviations: MC, Monte Carlo; PBPK, physiologically based pharmacokinetic; POD, point of departure.

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