Adhesion molecule expression differs among monocyte subsets between human immunodeficiency virus (HIV)-1 infected and HIV-uninfected participants. Whole blood samples from 49 HIV-1 infected and 19 HIV-uninfected participants were stained for monocyte subset surface markers (CD14 and CD16) and adhesion molecules (lymphocyte function-associated antigen 1 [LFA-1], macrophage-1 antigen [Mac-1], CD11c/CD18). The relative proportions of monocyte subsets and surface expression of adhesion molecules were analyzed by flow cytometry. (A) Summary data of monocyte subset representation among HIV-negative (HIV−) and HIV-positive (HIV+) participants are shown. (B) Representative dot plots for the integrins LFA-1, Mac-1, and CD11c/CD18, on each monocyte subset are shown. (C) Comparative summary data of monocyte subsets for adhesion molecules (CD11a, CD11b, and CD11c) for HIV− and HIV+ participants are displayed. MFI, mean fluorescence intensity.
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