Figure 1.
Individual susceptibility to theStreptococcus dysgalactiae subspeciesequisimilis (SDSE) necrotizing fasciitis (NF)-isolate-mediated fibrinolysis. Whole blood from resistant or susceptible donors was mixed with SDSE NF-isolate supernatants, and clot formation and lysis were analyzed using a roTeg analyzer. (A) Thromboelastogram of resistant blood phenotype. (B) Thromboelastogram of susceptible blood phenotype. (C) Clot and lysis parameters of resistant blood phenotype. Values are calculated by pooling the results of experiments from 4 different resistant donors. (D) Clot and lysis parameters of susceptible blood phenotype. Values are calculated by pooling the results of 3 independent experiments carried out on a single susceptible donor. Mean values are reported ± standard error of the mean. Significance was calculated using the pairedt test (**,P < .01; ****,P < .001). Abbreviations: CFT, clot formation time; LI30, lysis index at 30 minutes; LI45, lysis index at 45 minutes; MCF, monocyte chemoattractant protein; ML, maximum lysis; n.a., infinite clot formation time for weak clots (maximum clot firmness <20 mm).

Individual susceptibility to theStreptococcus dysgalactiae subspeciesequisimilis (SDSE) necrotizing fasciitis (NF)-isolate-mediated fibrinolysis. Whole blood from resistant or susceptible donors was mixed with SDSE NF-isolate supernatants, and clot formation and lysis were analyzed using a roTeg analyzer. (A) Thromboelastogram of resistant blood phenotype. (B) Thromboelastogram of susceptible blood phenotype. (C) Clot and lysis parameters of resistant blood phenotype. Values are calculated by pooling the results of experiments from 4 different resistant donors. (D) Clot and lysis parameters of susceptible blood phenotype. Values are calculated by pooling the results of 3 independent experiments carried out on a single susceptible donor. Mean values are reported ± standard error of the mean. Significance was calculated using the pairedt test (**,P < .01; ****,P < .001). Abbreviations: CFT, clot formation time; LI30, lysis index at 30 minutes; LI45, lysis index at 45 minutes; MCF, monocyte chemoattractant protein; ML, maximum lysis; n.a., infinite clot formation time for weak clots (maximum clot firmness <20 mm).

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