Diagnostic performance of individual and composite TFC. Forest plot of the diagnostic odds ratios and 95% confidence intervals. ^aConsidered positive if a pathogenic or likely pathogenic variant²⁵ is found in ARVC-associated genes as defined by the TFC: Plakophilin-2, Desmocollin-2, Desmoglein-2, Desmoplakin, Plakoglobin, or Transmembrane protein-43. ARVC, arrhythmogenic right ventricular cardiomyopathy; CI, confidence interval; CMR, cardiac magnetic resonance imaging; ECG, electrocardiogram; Echo, echocardiography; LBBB, left bundle branch block; PVC, premature ventricular complex; SAECG, signal-averaged ECG; SCD, sudden cardiac death; Sens, sensitivity; Spec, specificity; TAD, terminal activation duration; TFC, Task Force Criteria; TWI, T-wave inversion; VT, ventricular tachycardia.