Case 1. MRI brain: axial T1 postcontrast (A) and FLAIR (B) images at the time of diagnosis shows a predominantly non-enhancing lesion in the left frontotemporal area. Note midline shift and increasing vasogenic edema in the left frontotemporal at the time of progression as seen on axial T1 post contrast (C) and FLAIR (D) images. The patient did not respond to steroids and did not receive bevacizumab. She progressed clinically and required specialized institutional nursing care for several months before she died.