Graphical representation of clinical response experienced by patients treated with temozolomide (TMZ) for refractory pituitary tumors. Time is represented on x-axis, with time 0 denoting the point of first treatment with temozolomide. The time between diagnosis of the pituitary tumor and initiation of temozolomide is noted on the left. Four patients in the series are deceased (“X”), 3 are living. Radiologic progression is notated by a black arrow, while radiologic regression, as occurred in 3 patients during treatment, in notated by an asterisk.