Mouse PK profile of RA306. (A) RA306 time course concentration after IV administration at 3 mg/kg in plasma (dark circle) or after per os administration at 10 mg/kg in plasma (blue square), heart (blue star), and brain (blue triangle). n = 3 male C57BL/6 mice per time point. (B) Determination of PK parameters of RA306 in male C57BL/6 mice after IV (3mg/kg) and PO administration (10 mg/kg) using a non-compartmental model and WinNonLin software (Phoenix, version 6.4).