Global protein statistical analysis. (A–C) Wilcoxon rank-sum analysis of (A) Control samples vs. all cancer samples, (B) CA_cancer vs CA_control, (C) AA_cancer vs AA_control. (D) Paired t-test of CA cancer vs AA cancer samples. Red points indicate proteins with statistically significant increased levels in the serum; green points for significantly decreased levels; blue dotted lines indicate the threshold of significance (p = 0.05). Protein fold changes are indicated within parentheses.