Fig. 4.
Expression of p53 after [A] photon-RT and [B] 12C-RT. Expression of p53 was analysed 24 h after irradiation with either photons or 12C. C33a: 2/7 Gy photons → 1.4-fold (P = 0.0035)/1.3-fold (P = 0.0037) increase. 0.5/2 Gy 12C → 1.1-fold (P = 0.0066)/1.2-fold (P = 0.0001) increase. Caski: 2/7 Gy photons → 2.3-fold (P = 0.0097)/2.8-fold (P = 0.003) increase. 0.5/1/2 Gy 12C → 3.4-fold (P = 0.0508)/5.4-fold (ns)/4.2-fold (P = 0.0259) increase. W12: 2/7 Gy photons → 0.5-/0.3-fold decrease (ns). 0.5/1/2 Gy 12C → 0.8-/0.9-/0.9-fold decrease (ns). S12: 2/7 Gy photons → 1.9-fold (P = 0.00722)/3.4-fold (P = 0.0526) increase. 0.5/1/2 Gy 12C → 1.6-fold (P = 0.0178)/1.3-fold (P = 0.0043)/1.7-fold (P = 0.0292) increase. ns = not significant.

Expression of p53 after [A] photon-RT and [B] 12C-RT. Expression of p53 was analysed 24 h after irradiation with either photons or 12C. C33a: 2/7 Gy photons → 1.4-fold (P = 0.0035)/1.3-fold (P = 0.0037) increase. 0.5/2 Gy 12C → 1.1-fold (P = 0.0066)/1.2-fold (P = 0.0001) increase. Caski: 2/7 Gy photons → 2.3-fold (P = 0.0097)/2.8-fold (P = 0.003) increase. 0.5/1/2 Gy 12C → 3.4-fold (P = 0.0508)/5.4-fold (ns)/4.2-fold (P = 0.0259) increase. W12: 2/7 Gy photons → 0.5-/0.3-fold decrease (ns). 0.5/1/2 Gy 12C → 0.8-/0.9-/0.9-fold decrease (ns). S12: 2/7 Gy photons → 1.9-fold (P = 0.00722)/3.4-fold (P = 0.0526) increase. 0.5/1/2 Gy 12C → 1.6-fold (P = 0.0178)/1.3-fold (P = 0.0043)/1.7-fold (P = 0.0292) increase. ns = not significant.

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