Gonadotropin, androgen, and insulin receptor expression (median + 95% CI). (A) LHCGR was higher in control and PCOS (GLCs) (n = 6) than in control and PCO GCs from small antral follicles (****P < 0.0001, **P < 0.01) (n = 49, n = 49). LHCGR was higher in PCOS GLCs than in controls (P = 0.051). LHCGR expression did not significantly differ between PCO and control GCs; however, in the PCOS group, a subset of samples (20%, 10 of 49) had an expression between 5 and 20 times higher than the mean expression of LHCGR. (B) Scatter plot of LHCGR in control and PCO GCs demonstrating individual PCO samples with higher LHCGR. (C) Median FSHR expression was higher in control and PCO GCs than in control and PCOS GLCs (***P < 0.001, **P < 0.01). FSHR expression was lower in PCO GCs than in controls (*P = 0.03). FSHR expression was the same in control and PCOS GLC. (D) AR expression was 3.5-fold lower in control GLCs than in GCs (*P < 0.05). AR in PCO GCs was half that of control samples (**P < 0.01). AR in PCOS GLCs was similar to that in control GLCs. (E) INSR expression was the same in control and PCO GCs and GLCs. (F) AR and FSHR expression were positively correlated (P = 0.006, r = 0.44).