—Chromatin accessibility changes relative to proximal/distal location and cell type specificity. (A) The percentage of proximal elements, distal elements, and unannotated elements for each category of DHS sites. (B) Histogram of specificity scores for DHS sites identified in this study compared with DHS sites detected in 32 different tissue and cell types (Thurman et al. 2012). A high specificity score indicates the DHS site is specific to a small number of cell types. A low specificity score indicates the DHS site is shared across many cell types. The DHS site categories are separated into proximal elements (C) and distal elements (D). H–C, human–chimpanzee internal branch; H-C-G, human–chimpanzee–gorilla internal branch.