Longitudinal weight glycemia phenotypes in the SEARCH for Diabetes in Youth Study. Clusters were derived from baseline and follow-up measures of BMIz and HbA1c over a mean of 8.2 y. Clusters were named based on their main exposure, where high HbA1c is denoted by “Hyperglycemia” (H) and elevated BMIz is denoted by “Adiposity” (A). Four clusters were identified: The Referent Cluster (n = 195, 34.2%), the Hyperglycemia Only Cluster (n = 53, 9.3%), the Elevated Weight Only Cluster (n = 206, 36.1%), and the Elevated Weight with Increasing Hyperglycemia Cluster (n = 116, 20.4%). (A) Scatter plot of BMIz and HbA1c, colored by cluster, at both time points. (B) Cluster trajectories of BMIz and HbA1c between baseline and follow-up visit. EW, Elevated Weight Only Cluster; EWH, Elevated Weight with Increasing Hyperglycemia Cluster; H, Hyperglycemia Only Cluster; R, Referent Cluster.