Fig. 4
![Least squares means (LSM; ±s.e.) change from baseline in Montgomery Åsberg Depression Rating Scale total score over time for patients with (a) high sleep disturbance [baseline Hamilton Rating Scale for depression (HAMD) sleep disturbance factor score (sum of items 4 + 5+6) ⩾ 4] and (b) low sleep disturbance [baseline HAMD sleep disturbance factor score (sum of items 4 + 5+6) < 4; last observation carried forward; pooled modified intent-to-treat population]. XR, Extended release. a Pooled scores for week 6 of studies 1 and 2 and for week 8 of studies 3 and 4. * p < 0.05; *** p < 0.001 vs. placebo.](https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/ijnp/16/8/10.1017_S146114571300028X/1/s146114571300028x_fig4.gif?Expires=1750700221&Signature=M84yeF2eF744Sa-4xG7cJMrk2wsTIUiuvYJykZJH2Xcqhjx9aN4dkhUw8nUJPkXGu73~iovGNsxrfCdl1upNx9y54fIhYfNbIg1fKAfqunhUjcFhP0dvKOdJ7ZncSqPoMJJ~VPEZtZodhdr2aIKVKlrmby-clNC-ungERw9-ltr1AfCyJfmuvLG4JLjM2LR6KdvpFCJb54~sAskJJ-qRK8JmFGWcz4InkVDjJ3IH7fr9VeWRwnRJL4nH5NNORIhSDa4VvWYgDRx7YrXUbcr6GjIo-cxAssTuK-WO3-r4grXMruAv9e4~qLkh4xh01sAKESdJZQPhZKoUA5HxZ2dj0g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Least squares means (LSM; ±s.e.) change from baseline in Montgomery Åsberg Depression Rating Scale total score over time for patients with (a) high sleep disturbance [baseline Hamilton Rating Scale for depression (HAMD) sleep disturbance factor score (sum of items 4 + 5+6) ⩾ 4] and (b) low sleep disturbance [baseline HAMD sleep disturbance factor score (sum of items 4 + 5+6) < 4; last observation carried forward; pooled modified intent-to-treat population]. XR, Extended release. a Pooled scores for week 6 of studies 1 and 2 and for week 8 of studies 3 and 4. * p < 0.05; *** p < 0.001 vs. placebo.
