Fusion kinases in acral melanoma. A) The BRAF fusion junctions reside downstream of the autoinhibitory RAS binding domain (RBD) and upstream of the kinase domain of BRAF. ERC1-BRAF contains a coiled coil domain that promotes dimerization is contributed by ERC1. B) The predicted NTRK3 fusion proteins are missing most of the extracellular domain of NTRK3 and may contain the transmembrane domain in addition to the kinase domain. The MYO5A-NTRK3 fusion contains coiled-coil domains contributed by MYO5A. C) The predicted ATP2B4-PRKCA fusion protein lacks the regulatory calcium binding domains (C1, C2, C3).