Forest plots for (A) trial-defined MAE and (B) mortality. The individual endpoints building the composite endpoint major adverse cardiovascular events are provided in Table 2. For the analysis of death, all-cause mortality was used of all trials, except the PIONEER AF-PCI trial, which only reported data on cardiovascular mortality. CI, confidence interval; DAT, dual antithrombotic therapy; HR, hazard ratio; IV, inverse variance; SE, standard error; TAT, triple antithrombotic therapy; TE, treatment effect.