Everolimus treatment decreases blood pressure and attenuates renin suppression. (A and B) 7-Day home blood pressure measurements showed a significant decrease in systolic (P = 0.001, adjusted P = 0.011 d15 vs d0 and P > 0.999 day 28 vs d0) and diastolic (P < 0.026, adjusted P = 0.042 d15 vs d0 and P > 0.999 d28 vs d0) blood pressure. (C) Cardiac index (P = 0.179) was not significantly changed. (D and E) Renin increased significantly after everolimus treatment (P < 0.0001, adjusted P = 0.001 d15 vs d0 and P = 0.023 d28 vs d0). (F) Heart rate (P = 0.168) and (G) copeptin (P = 0.937) showed no significant difference. Subjects who showed a marked decrease of plasma aldosterone after everolimus treatment are marked as responders in red; nonresponders are marked in gray. (D) Data are shown with median and IQR. Data analysis with nonparametric one-way ANOVA (Friedman) and Dunnett post hoc test. n = 10 for blood pressure and heart rate, n = 11 for renin as a result of missing data, n = 12 for cardiac index and copeptin. *P < 0.05, ***P < 0.001.