Summary of results for GWAS of loss of visual function in multiple sclerosis. (A) Manhattan plot depicting P-values from analyses assessing the pooled association between genetic variants and risk of sustained LCLA from the discovery (CombiRx) and replication (JHU-LCLA). One variant (rs72830848) was potentially associated with sustained LCLA at the 5 × 10⁻⁸ significance level in the pooled analysis. (B) Kaplan Meier plot comparing rate of sustained LCLA for individuals with the CC genotype relative to individuals with TC or TT genotype. Individuals with the CT or TT genotype were at an over 2-fold increase risk of sustained LCLA change relative to individuals with the CC genotype (HR: 2.25; 95% CI: 1.70 to 2.98; P-value = 3.98 × 10⁻⁸).