Phosphorylated AMPK levels inversely correlate with the mature SREBP-1 protein in the presence of selective AHR ligands. A, SEB-1 cells were treated with SGA360 (10 µM) or SGA315 (10 µM) in media containing lipid-depleted FBS for 24 h, AMPK and pAMPK (T172) protein levels were determined by WES. B, SGA360 (10 µM) or SGA315 (10 µM) was administered to SEB-1 cells in the presence of high glucose (25 mM) or high delipidated serum (20% FBS). C, Protein expression of SREBP-1, AMPK, and pAMPK (T172) was examined by WES analyses, and quantified. Regression analysis comparing pAMPK and mSREBP-1 protein levels. Data are presented as mean ± SD, n = 3; significance was determined by one-way ANOVA.