Selective AHR activation leads to a decrease in the transcriptionally active mSREBP-1 protein level without altering factors involved in SREBP proteolytic processing. SEB-1 cells were treated with SGA360 (10 µM) or SGA315 (10 µM) for 24 h in delipidated media, and SREBP-1 expression was examined at (A) mRNA or (B) protein level. C, Upon 24 h of ligand exposure, mRNA levels of SCAP, INSIG1, S1P, and S2P were assessed by qRT-PCR and (D) protein expression of SCAP and INSIG1 was analyzed by WES capillary system. Data are presented as mean ± SD, n = 3; significance was determined by one-way ANOVA.