Selective AHR modulators are able to decrease lipid synthesis in SEB-1 cells. SEB-1 cells were treated with SGA360 (10 µM) or SGA315 (10 µM) for 48 h in the presence of linoleic acid and insulin. Lipids were stained by Oil Red O (A, B) or using live cell lipid imaging kit (C, D). E, Upon 48 h of ligand exposure (10 µM) in delipidated media, SEB-1 cells were incubated for an additional 24 h in stable isotope containing media (see Materials and Methods section) in the presence of ligands.U-¹³C-incorporated oleic acid and stearic acid were measured by liquid chromatography–mass spectrometry. Data are presented as mean ± SD, n = 3; significance was determined by one-way ANOVA.