Correlation between the presence of enterovirus VP1 and inflammatory cell infiltration to acinar cells/islets and CXCL10/CXCR3 expression in the FT1DM pancreas. (A–F) Serial sections. Original magnification, ×100; scale bars, 50 μm (20 μm in each inset). See the magnified and detailed images of insets in an online repository (11). (A) VP1 in the FT1DM pancreas. Inset 1 shows VP1 in exocrine acinar tissues (brown, arrows). Inset 2 shows VP1 in islets (brown, arrows). (B) CD68⁺ macrophages (brown) infiltrate to the exocrine pancreatic tissues (inset 1, arrows) and islets (inset 2, arrows). (C) CD8⁺ T cells (brown) infiltrate to the exocrine pancreatic tissues (inset 1, arrows) and islets (inset 2, arrows). (D) A few β cells were densely stained for insulin (brown) in FT1DM islets (inset 2, arrows). Some β cells are stained faintly. (E) CXCL10 (brown) in exocrine pancreatic tissues (inset 1, arrows) surrounded by MNCs are stained faintly, and islets cells (inset 2, arrows) are densely stained for CXCL10. Remaining islet cells are faintly stained for CXCL10. (F) CXCR3⁺ MNCs (brown) infiltrate around the exocrine pancreatic tissues (inset 1, arrows) and islets (inset 2, arrows).