Tissue and cellular localization of proteins encoded by causative genes. The variants identified in our study are fully colored in the figure. ALS, acid-labile subunit; COL 2, collagen type II; COL 9, collagen type IX; COL 10, collagen type X; COL 11, collagen type XI; COMP, cartilage oligomeric matrix protein precursor; FGFR3, fibroblast growth factor receptor 3; IGF1 – insulinlike growth factor-1; IGF1R, insulinlike growth factor-1 receptor; IGFBP3, insulinlike growth factor-binding protein 3; IHH, Indian hedgehog; MATN3, matrilin 3; NPR2, natriuretic peptide receptor 2; PTH1R, parathyroid hormone 1 receptor.