Total body irradiation (TBI)-induced gene expression changes in mice small intestine crypts. Five mice were exposed to 8 Gy TBI, then BMCs were injected into mice through the lateral canthus vein. Mice were euthanized 10 months after TBI, then small intestinal crypts were obtained from the rectum, as described in the Materials and Methods. Mice in the control group were of the same age and number as those in the TBI group. (A) Venn diagram showing the overlap and significantly differentially expressed genes between the control mice and TBI mice small intestinal crypts; (B) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis 10 months after mice were exposed to TBI; (C) heat map of significantly differentially expressed genes enriched in the KEGG pathway; (D) relative expression of downregulated (D) and upregulated (E) significantly differentially expressed genes, verified by RT-PCR (n = 3 in each group).