Spectrum of LH secretion patterns of men presenting with FHH. Subjects underwent detailed neuroendocrine profiling (every 10 minutes × 12 hours) to chart LH secretion pattern. Inverted triangles depict LH pulses. Shaded region depicts the normal reference range (27). Subject 1 underwent only 8 hours of sampling and had recovered HPG axis function at the time of the neuroendocrine evaluation (normal serum T levels).