Representative graphs of LH secretion patterns in three men with FHH. Subjects underwent neuroendocrine profiling (every 10 minutes × 12 hours) to chart GnRH-induced LH secretion. (A) Subject 10 was the lone patient with an apulsatile LH secretion pattern. (B) Subject 6 displayed sleep-entrained pulses (hatched bar depicts sleep period). (C) Subject 8 exhibited a normal LH secretion pattern with characteristic peaks, as observed in healthy controls (42). Shaded region represents the normal reference range (27). Inverted triangles indicate LH pulses.