Rate of clinical relevant improvement in HRQoL within 8 months in prespecified subgroups. CI, confidence interval; CRT, cardiac resynchronization therapy; GFR, glomerular filtration rate; HRQoL, health related quality of life; ICD, implantable cardioverter defibrillator; LV, left ventricular; NT-proBNP, N-terminal pro-brain natriuretic peptide; NYHA, New York Heart Association.