Renal cortical mRNA expression levels for ICAM-1 and VEGF-A, and urinary ICAM-1 levels in the study groups. The results of RT-PCR for renal cortical ICAM-1 (a), ELISA for urinary ICAM-1 (b) and RT-PCR for renal cortical VEGF-A (c) are shown. The ICAM-1 and VEGF-A mRNA values were normalized to GAPDH values and expressed as a relative quantification. The horizontal dotted lines show the average values observed in WKY-NTS (−) rats. Data are means ± SEM. ^####P < 0.0001: WKY-NTS (−) versus WKY-Vehicle, *P < 0.05, ***P < 0.001: WKY-Vehicle versus WKY-TM.