Urinary total protein levels, serum Cr levels and total kidney weight in the study groups. (a) Urinary total protein levels, (b) serum Cr levels, (c) total kidney weight and (d) kidney weight/body weight ratio of WKY rats with nephritis treated with either vehicle (WKY-Vehicle) or RH-TM (WKY-TM) are shown. The horizontal dotted lines show the levels of proteinuria, serum Cr and kidney weight in WKY rats without nephritis [WKY-NTS (−)]. Data are means ± SEM. ##P < 0.01: WKY-NTS (−) versus WKY-Vehicle; **P < 0.01, ***P < 0.001, ****P < 0.0001: WKY-Vehicle versus WKY-TM.