Figure 6.
The scheme of mechanism of SIRT3 in mitophagy and tumorigenesis of Cr(VI)-transformed cells. Chronic exposure of the cells to Cr(VI) at low dose causes malignant cell transformation. The malignantly transformed cells exhibit constitutive activated Nrf2 and SIRT3, leading to mitophagy suppression, cell survival and tumorigenesis of Cr(VI)-transformed cells.

The scheme of mechanism of SIRT3 in mitophagy and tumorigenesis of Cr(VI)-transformed cells. Chronic exposure of the cells to Cr(VI) at low dose causes malignant cell transformation. The malignantly transformed cells exhibit constitutive activated Nrf2 and SIRT3, leading to mitophagy suppression, cell survival and tumorigenesis of Cr(VI)-transformed cells.

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