Effects of DEHP and DiNP on litter size and average live pup weight. Adult female CD-1 mice were orally dosed for 10 days with either vehicle control (corn oil), DEHP (20 µg/kg/day–200 mg/kg/day), or DiNP (20 µg/kg/day–200 mg/kg/day). Females were mated with untreated male mice for breeding trials immediately post-dosing, 3 months post-dosing, and 9 months post-dosing. Live and dead pups were counted to determine the litter size on PND 0 (Panels A–C, n = 8––19 mice/group, n = 5–18 mice/group, and n = 4–14 mice/group, respectively). Live pups were weighed collectively and an average was taken on PND 0 to determine the average live weight (Panels D–F, n = 8–19, 5–16, and 4–15 mice/group, respectively). Data are represented as means ± SE. Statistically significant difference when compared with control (p ≤ .05) is denoted with an asterisk (*). Borderline statistical significance (.05 < p ≤ .10) is denoted with a caret (^).