Effects of DEHP and DiNP on time to mating. Adult female CD-1 mice were orally dosed for 10 days with either vehicle control (corn oil), DEHP (20 µg/kg/day–200 mg/kg/day), or DiNP (20 µg/kg/day–200 mg/kg/day). Females were mated with untreated male mice for breeding trials immediately post-dosing (Panel A, n = 7–21 mice/group), 3 months post-dosing (Panel B, n = 7–18 mice/group), and 9 months post-dosing (Panel C, n = 10–20 mice/group) and checked every morning and afternoon until a copulatory plug was observed or until 14 days had elapsed. Time to mating was calculated as the days between male introduction and observation of a copulatory plug. Data are represented as means ± SE. Statistically significant difference when compared with control (p ≤ .05) is denoted with an asterisk (*). Borderline statistical significance (.05 < p ≤ .10) is denoted with a caret (^).
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