Proposed impaired bilateral dorsal network (yellow/orange) in this family, based on functional and structural imaging results. ↓ = reduced; ↑ = increased; AF = arcuate fasciculus (d = direct segment; a = anterior segment); AG = angular gyrus; CBT = corticobulbar tract; Cn = caudate nucleus; CST = corticospinal tract; GP = globus pallidus; IFOF = inferior fronto-occipital fasciculus; Pu = putamen; PM/IFG = premotor cortex/inferior frontal gyrus; SMC = sensori-motor cortex; STG = superior temporal gyrus; Th = thalamus.