3D heat maps generated by GBM. (A) Entorhinal cortex; (B) parahippocampal gyrus; (C) inferior temporal cortex; (D) posterior cingulate; and (E) the prefrontal region of interest. For each heat map, four age ranges are represented: 50–59, 60–69, 70–79 and 80–89 years. Flortaucipir SUVR is on the x-axis, cortical thickness (inverted scale) on the y-axis and predicted memory z-score on the z-axis as depicted by the colour code for each individual graph. Heat map ranges are set at the 3rd and 97th percentiles of the distribution of each biomarker by decade of age. The key findings are that the entorhinal cortex shows the strongest associations between the biomarkers and memory z-score.