Scatter plots showing biomarker values as a function of disease severity. Biomarkers plotted by estimated years to symptom onset (EYO) for mutation non-carriers (green circles), asymptomatic carriers (orange triangles), and symptomatic carriers (red squares) for (A) precuneus PiB PET, (B) FDG PET, (C) cortical thickness from MRI, and (D) tau PET. The dashed line shows the model fit for mutation carriers and the solid line is for non-carriers. Aβ = amyloid-β.